There’s nothing more comforting than the savory, cheesy aroma of Swiss Chicken Casserole baking in the oven. This dish combines tender chicken breasts, creamy sauce, and the nutty flavor of Swiss cheese for a meal that feels like a warm hug on a chilly evening.

I first discovered this recipe years ago when searching for an easy dinner option that would still feel indulgent. Since then, it’s become my go-to comfort food, perfect for family dinners or potlucks alike.

Ready to dive into a dish that's as simple as it is satisfying? Let’s get started!

Why You’ll Love This Swiss Chicken Casserole

Get ready to fall head over heels for this classic casserole. Here’s why it’s bound to become a regular in your dinner rotation:

First, it’s incredibly easy to make. With just a handful of simple ingredients and a prep time of under 15 minutes, this recipe is perfect for busy weeknights.

The rich, creamy sauce is the star of the show. Made with sour cream and cream of chicken soup, it pairs beautifully with the mild, nutty Swiss cheese, creating a flavor profile that’s truly unforgettable.

You’ll also love how budget-friendly this dish is. Using pantry staples and affordable ingredients, you can whip up a hearty meal that feeds the whole family without breaking the bank.

Finally, this casserole is a crowd-pleaser. Whether you’re serving picky eaters or hosting a potluck, it’s always a hit. The combination of tender chicken and gooey cheese is universally loved.

Ready to put it together? Let’s break down what you’ll need.

Ingredients Notes

The magic of this Swiss Chicken Casserole lies in its simple, everyday ingredients that combine to create extraordinary flavor.

Chicken Breasts: Boneless, skinless chicken breasts work best here. Their mild flavor allows the sauce and cheese to shine. If you prefer, chicken thighs can also be used for a juicier texture.
Swiss Cheese: The nutty, slightly tangy flavor of Swiss cheese is essential. You can use pre-sliced cheese for convenience or grate a block of Swiss for even coverage.
Cream of Chicken Soup: This creamy base is the foundation of the casserole's rich sauce. Opt for low-sodium varieties if you’re watching your salt intake.
Sour Cream: Adds tanginess and creaminess to the sauce. Greek yogurt can be substituted if you want a lighter option.
Seasoned Stuffing Mix: Used as a topping, this adds crunch and flavor. Herb-seasoned stuffing mixes work best, but plain breadcrumbs can be substituted in a pinch.
Butter: Melted butter binds the stuffing mix, helping it crisp up beautifully in the oven.

No special equipment is needed—just a baking dish, a mixing bowl, and a trusty oven.

How To Make This Swiss Chicken Casserole

Making this casserole is as simple as layering a few ingredients and letting the oven do the work. Here’s a step-by-step guide to ensure success:

Prep Your Ingredients: Preheat your oven to 375°F (190°C) and lightly grease a 9x13-inch baking dish. While the oven heats, gather your ingredients and set everything within easy reach.
Layer the Chicken: Arrange the chicken breasts in a single layer at the bottom of the prepared baking dish. Season them lightly with salt and pepper.
Make the Sauce: In a mixing bowl, combine the cream of chicken soup and sour cream. Stir until smooth, then spread the mixture evenly over the chicken.
Add the Cheese: Lay slices of Swiss cheese over the sauce, ensuring the chicken is completely covered. The cheese will melt into the sauce, creating a velvety texture.
Top with Stuffing: In a separate bowl, mix the stuffing mix with the melted butter. Sprinkle this mixture evenly over the top of the casserole. The stuffing will form a crunchy, golden-brown topping as it bakes.
Bake to Perfection: Place the dish in the oven and bake uncovered for 40-45 minutes, or until the chicken is cooked through and the topping is golden brown. Serve hot, straight from the oven!

This dish pairs beautifully with a simple green salad or steamed vegetables for a complete meal.

Storage Options

Got leftovers? Here’s how to store and enjoy them later:

Refrigerator: Store in an airtight container for up to 3 days. Let the casserole cool completely before transferring it to the fridge.
Freezer: This casserole freezes well! Wrap the baking dish tightly in plastic wrap, then foil, and freeze for up to 3 months. Thaw in the refrigerator overnight before reheating.
Reheating: To reheat, cover the casserole with foil and bake at 350°F (175°C) for 20-25 minutes, or until heated through. For single portions, use the microwave on medium power for 2-3 minutes.

Variations and Substitutions

One of the best things about this recipe is how versatile it is. Here are a few ideas to make it your own:

Swap the Cheese: Not a fan of Swiss? Try mozzarella, provolone, or even sharp cheddar for a different flavor profile.
Add Veggies: Sneak in some nutrition by adding sautéed mushrooms, spinach, or steamed broccoli to the casserole.
Use Rotisserie Chicken: For an even quicker meal, use shredded rotisserie chicken instead of raw breasts. Adjust the baking time to 25-30 minutes.
Gluten-Free Option: Substitute the stuffing mix with gluten-free breadcrumbs to make this dish gluten-friendly.
Spice it Up: Add a dash of paprika, garlic powder, or Italian seasoning to the sauce for extra flavor.

Feel free to experiment with different ingredients and make this recipe truly your own.

This Swiss Chicken Casserole is proof that comfort food doesn’t have to be complicated. Whether you’re cooking for your family or hosting guests, this recipe is guaranteed to impress. Give it a try, and don’t forget to share your favorite twists and tips in the comments below!